Jafarifar, F., Dietrich, R.C., Hizney, J.M. and Padgett, R.A. Biochemical defects in minor spliceosome function in the developmental disorder MOPD I. RNA 2014; 20: 1078 - 1089. (lerner.ccf.org)
The mechanism is thought to be similar to that of the human spliceosome whose malfunctioning can lead to several diseases among which neurodegeneration and cancer. (sciencedaily.com)
They also found remarkable similarities in structure and function between spliceosome RNAs and group II introns, an evolutionarily - ancient class of self - splicing, catalytic RNA found in all major branches of life. (sciencedaily.com)