The phrase "splicing machinery" refers to the biological process in cells that joins together different pieces of genetic material, like a molecular tool. Full definition
«RNA splicing machinery offers new drug target.» (sciencedaily.com)
SMN1 contributes to the assembly of the pre-mRNA splicing machinery, and loss of SMN1 has been hypothesized to cause disease through disruption of mRNA splicing. (smafoundation.org)
The therapy is an 18 - letter string of DNA that corrects aberrant splicing by binding a unique sequence on SMN2 «s messenger RNA located just downstream of the crucial seventh exon, thereby obstructing components of the RNA splicing machinery (see «Bring to one's antisenses»). (smafoundation.org)