The researchers found that the exosomes that had been purposely stressed contained a molecule called p38 MAPK that is known to be linked to delivery by speeding up certain factors associated with births that included the aging of the placenta and increasing sterile inflammation of the uterus. (sciencedaily.com)
This second condition is called sterile inflammation, and when it goes awry, it contributes to a wide range of seemingly unrelated medical conditions, from Alzheimer's disease to diabetes to various liver conditions. (scientificamerican.com)
This discovery leads to a major revision of previous paradigm by broadening focus of anti-aging drug discovery and development to include a new likely cellular source of age - associated chronic systemic sterile inflammation. (everonbio.com)