In addition, our data evidence that LA via the Rho - associated kinase - mediated pathway promotes stress fiber formation, which exerts a main role in the morphological changes associated with apoptotic cell death. (healthimpactnews.com)
Detailed investigations demonstrated that the formation of stress fibers and cell - cell junctions created the force necessary for the condensation process, all mediated by MSCs through the actomyosin cytoskeletal axis. (stemcellsportal.com)
It is not clear how tensile forces generated by stress fiber contraction, strengthen adhesions at the cell front but disassemble adhesions at the cell rear allowing cell translocation. (science.institut-curie.org)