Evaluation of MP - 10, a PDE10 inhibitor, on BACHD transgenic rats using dual recording of single units in Globus Pallidus and Subthalamic nucleus S. ZHONG, G. TOMBAUGH, L. MRZLJAK, V. BEAUMONT, C. SCHMIDT, M. ZALESKA, C. CHANG, A. GHAVAMI... Abstract / Posters (psychogenics.com)
Chorea, a loss of motor control that is characteristic of HD physical symptoms, is thought to reflect a dysfunction of the indirect pathway (IP) drive arising from a deficit of striatal output to globus pallidus (GP), which in turn innervates subthalamic nucleus (STN). (psychogenics.com)
The experiment called into question the leading theory of how the technology works — activation of an area called the subthalamic nucleus. (scientificamerican.com)