We generated knockin / knockout mice that expressed only open syntaxin - 1B. (science.sciencemag.org)
In mammalian cells the SM protein Munc18 - 1, which interacts with the SNARE protein syntaxin, is an essential component of the tethering machinery. (biologie.uni-osnabrueck.de)
When elevating calcium ion concentration directly at the presynaptic terminal with the use of caged calcium, cleavage of SNAP - 25 by botulinum toxin A (BoNT / A) produced a strong reduction in the calcium sensitivity for release, whereas cleavage of syntaxin using BoNT / C1 and synaptobrevin using tetanus toxin (TeNT) produced an all - or - nothing block without changing the kinetics of remaining vesicles. (science.sciencemag.org)