In addition, neurofibrillary tangles pathology was observed in apes that exhibited plaques and moderate or severe cerebral amyloid angiopathy and in one individual with virtually no amyloid beta pathology. (sciencedaily.com)
Postmortem studies of human brains and neuroimaging studies have suggested that the disease, especially the neurofibrillary tangle pathology, begins in the entorhinal cortex, which plays a key role in memory. (newsroom.cumc.columbia.edu)
Identifying the molecular triggers for the onset of AD - related cognitive decline presently requires the use of suitable animal models, such as the 3xTg - AD mice, which develop both amyloid and tangle pathology. (sens.org)