Professor Claude M. Wischik, co-founder and Executive Chairman of TauRx Therapeutics, along with colleagues at the University of Aberdeen, has devoted nearly 30 years to investigating the structure and role of tau tangles in the development of Alzheimer's, frontotemporal dementia (FTD) and other neurodegenerative diseases. (taurx.com)
Those worsening symptoms are presumed to be caused by more rapid buildup of tau tangles in the APOE4 carriers. (sciencenews.org)
When this network is disrupted by tau tangles, it can trigger a chain reaction of damage in the memory and cognitive circuitry of the brain, accelerating mental deterioration. (discovermagazine.com)