In August, 1997, Nobelist Thomas Cech of the University of Colorado at Boulder and colleagues at Geron isolated the human gene for telomerase reverse transcriptase (hTRT)-- an enzyme that reknits loosening telomeres and extends a cell's life. (scientificamerican.com)
Tocotrienols also inhibited protein kinase C activity, which caused down - regulation of human telomerase reverse transcriptase (hTERT) expression, thereby reducing telomerase activity. (lmreview.com)
Variants in the gene called Telomerase Reverse Transcriptase (TERT) on chromosome 5 that were associated with older IEAA were also associated with longer telomeres indicating a critical role for TERT in regulating the epigenetic clock, in addition to its established role of compensating for cell replication - dependent telomere shortening. (sciencedaily.com)