Virtually all of the hormone in the cream or patch gets into the bloodstream if it is put on thin areas of the skin such as the inner arms. (virginiahopkinstestkits.com)
It's effortless, in both directions but you do need to be careful around thinner areas to avoid scraping them. (1800petmeds.com)
One coat gives an excellent coverage, but left a few thin areas here and there. (h2obungalow.com)