In Class II engagement, it binds directly to the DNA in multiple locations and activates transcription of cartilage - related genes. (sciencedaily.com)
It does so by activating the transcription factor STAT3, which in turn inhibits expression of the miR - 34a gene by directly binding to it.» (sciencedaily.com)
Shedding new light on these elusive eRNAs, they showed that CBP, an enzyme that activates transcription from enhancers, binds directly to eRNAs. (sciencedaily.com)