By inactivating a gene linked to abnormally small brain size in humans, researchers have created the first ferret with a neurological mutation. (hhmi.org)
To confirm that the mutations that we identified in the GTPBP3 gene are responsible for the disease we have inactivated the gene in vitro in healthy cells. (sciencedaily.com)
After suppressing mitochondrial function using the drug antimycin, Chen and Birsoy saw that cells with mutations inactivating the gene ATPIF1 were protected against loss of mitochondrial function. (sciencedaily.com)