A single injection of targeted BNPs loaded with methotrexate completely resolved inflammation in a rat model of antigen - induced arthritis, while the same dose of free - methotrexate injected into the rat's bloodstream was ineffective. (sciencedaily.com)
Using a comprehensive profiling technique, the team was able to uncover a milieu of molecules known as specialized pro-resolving mediators (SPMs) in human breast milk and found that each of these molecules helped resolve inflammation and stimulate immune response in preclinical models. (sciencedaily.com)
They found that SPM levels were much lower in milk from mastitis and did not resolve inflammation and infection to the degree that breast milk from non-mastitis samples did. (sciencedaily.com)