Last year the labs of Mark Zylka and Ben Philpot at the University of North Carolina at Chapel Hill discovered that a class of drugs called topoisomerase inhibitors reduces the expression of long genes. (sciencedaily.com)
The mechanism of topoisomerase I poisoning by a camptothecin analog Proceedings of the National Academy of Sciences (Vol. (decode.com)
A class of anticancer compounds, called topoisomerase inhibitors, is shown by Cancer Center scientists to initiate antitumor responses in treatment - resistant cancers. (hopkinsmedicine.org)