While further validation is required, the method has the potential to lead to faster diagnosis of toxic liver side effects in patients. (sciencedaily.com)
In the new study, the approach was applied to simulate and compare the potentially toxic liver effects of fifteen different drugs at clinically relevant doses. (sciencedaily.com)
Ligation of the common bile duct (BDL), modeling cholestatic liver injury, resulted in a rapid onset of bacterial overgrowth; however, it took 24 injections of carbon tetrachloride (CCl4), modeling toxic liver injury, to observe bacterial overgrowth. (jcvi.org)