They found that L2 - deficient eggs were unable to undergo global transcriptional silencing, a process that normally happens in the final stages of egg growth. (sciencedaily.com)
MicroRNAs or miRNAs are short non-coding RNA sequences that can participate in regulating gene expression, through post transcriptional silencing of mRNAs. (innovationtoronto.com)
Beyond their potential significance in our understanding of human infertility, Cook - Andersen said these results are scientifically exciting because they indicate that L2 and mRNA decay play important roles in global transcriptional silencing. (sciencedaily.com)