Mice fed high folic acid in the treatment group had higher concentrations of unmetabolized folic acid in blood plasma and higher folate concentrations in the spleen when compared to mice in the control group. (sciencedaily.com)
The low activity of this enzyme in the human liver, combined with a high intake of folic acid, may result in unnatural levels of unmetabolized folic acid entering the systemic circulation. (wellnessmama.com)
It is also not clear whether unmetabolized tramadol has significant pain - relieving properties or if some individual dogs make substantially more of the M1 metabolite than other individual dogs. (marvistavet.com)