The meat of the matter is why the different adjustment procedures don't agree and if there is any way to get accurate enough temperature estimates to make useful estimates of the accumulated energy. (realclimate.org)
This fact proved sufficient to obtain useful estimates for global mean temperature changes. (data.giss.nasa.gov)
When a drug company must decide which target to pursue among pathologic pathways, this could provide useful estimates of each target's expected success rate.» (uchospitals.edu)