The incidence of uveal melanoma in Europe follows a gradient from the north to the south: 2 to 8 new cases per one million population, annually. (melgen.org)
One hundred and one patients with metastatic uveal melanoma at 15 centers in the United States and Canada were randomized to receive either selumetinib or standard chemotherapy. (sciencedaily.com)
This pathway is activated by mutations in the Gnaq and Gna11 genes, which occur in more than 85 percent of uveal melanoma patients; 84 percent of patients in this trial had one of the mutations. (sciencedaily.com)