One of the most serious classifications of this disease is known as diffuse scleroderma wherein the «sclerosis» (hardening of the tissue) occurs in the internal systems of the body, causing damage and widespread scarring to the skin as well as to various internal organs such as the lungs, kidneys, heart and gastrointestinal organs. (okyanos.com)
It is defined as a malfunction of the autonomic nervous system, which affects various internal organs including the large intestine. (catbreedsjunction.com)
Anal gland tumors are almost always malignant and may already have spread to regional lymph nodes and then to various internal organs by the time of the initial diagnosis. (brittonroadveterinaryclinic.com)