Experiments with rats have shown the crop fungicide vinclozolin can cause susceptibility to cancer and kidney defects, both of which can be transferred to offspring through methylation changes. (science.howstuffworks.com)
The amount of vinclozolin Skinner gave the rats was much higher than a person is likely to encounter, but «just knowing this mechanism exists might change the way we do medicine,» Skinner says. (discovermagazine.com)
Washington State University molecular biologist Michael Skinner had previously shown that sperm abnormalities induced by vinclozolin, a toxic fungicide used on wine grapes, strawberries, and other fruits, can pass from father to son for four generations in rats. (discovermagazine.com)