Animals vaccinated more than a week before viral challenge developed antibodies, an adaptive immune response, that were shown to be critical for protection. (sciencedaily.com)
In an efficacy study involving nonhuman primates that was specifically designed to evaluate the efficacy of AVI - 7288 after delayed treatment, a dose of 15 mg per kilogram per day for 14 days starting at 24, 48, and 96 hours after viral challenge provided 83 %, 100 %, and 83 % protection, respectively. (sciencedaily.com)
Here we have also tested the longevity of the Wolbachia infected flies in the absence of viral challenge (Figure 2A). (journals.plos.org)