There are many more differences between a home printer and a large web press. (stillpointdigital.com)
So far that I have found, CreateSpace is the cheapest by far for printing any perfect bound book unless you pay ahead or are up to using web presses (see below) at runs of ten thousand copies. (deanwesleysmith.com)
For longer runs, we have 2 offset plants featuring the largest fleet of Timsons web presses in the United States and numerous sheetfed presses. (edwardsbrothersmalloy.com)