The phrase "irreversible changes" refers to actions or events that cannot be undone or reversed. These changes are permanent and cannot be returned to their original state. Full definition
But between the lines, the truth comes out: there is more than enough readership to go around, and indie authors have made irreversible change in the industry. (goodereader.com)
We are at risk of pushing our climate system toward abrupt, unpredictable, and potentially irreversible changes with highly damaging impacts. (climatechangenationalforum.org)
Taking it for too long may cause irreversible changes to your milk supply. (abckidsinc.com)