Sentences with word «acetyltransferase»
Acetyltransferase is a word that describes an enzyme or a protein that helps transfer a molecule called acetyl from one substance to another. This process is important for many chemical reactions that happen inside our cells. Full definition
Activators of histone acetyltransferases (HAT) provide an alternative approach for the selective activation of gene expression, however little is known about the potential of HAT activators as drug therapies for PD.
link.springer.com
Deletion of choline acetyltransferase in enteric neurons results in postnatal intestinal dysmotility and dysbiosis — Carl D Johnson — The FASEB Journal
Identification of mureidomycin analogues and functional analysis of an N - acetyltransferase in napsamycin biosynthesis.
dCas9 fused to the catalytic domain of p300 acetyltransferase increases levels of H3K27ac histone modification at specified loci.
The responsiveness of the pineal β - adrenergic receptor that regulates serotonin - N - acetyltransferase activity is nearly ten times greater at the end of the light period (0600 to 1800 hours) than at the end of the dark period (1800 to 0600 hours).
Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.
Turnover and transformation of mitochondrial acetyl - CoA acetyltransferase into CoA - modified forms
Gcn5 is an enzyme known as a histone acetyltransferase which delivers molecular components making up an acetyl group to histone genes, allowing the genes to be switched on or off.
«If a substance was available to reduce the activity of acetyltransferase back to normal levels, the lack of spermine and thus the symptoms of epilepsy could be mitigated,» speculates Prof. Beck.
Zhang X, Peng D, Xi Y, Yuan C, Sagum CA, Klein BJ, Tanaka K, Wen H, Kutateladze TG, Li W, Bedford MT, Shi X. (2016) G9a - mediated methylation of ERα links the PHF20 / MOF histone acetyltransferase complex to hormonal gene expression.
For instance, her lab has shown that tubulin acetyltransferase (TAT), an enzyme that labels the cylindrical insides of microtubules, can act as a slow clock for the lifetime of a microtubule.
A small molecule activator of p300 / CBP histone acetyltransferase promotes survival and neurite growth in a cellular model of Parkinson's Disease
At sites of UV damage, E2F1 recruits the histone acetyltransferase GCN5, which acetylates histone H3K9 in order to open chromatin structure and increase accessibility to the damaged site by the DNA repair machinery.
Recently - published findings from scientists at Monash University in Australia revealed the presence of yet another complex component in weight maintenance: a protein named carnitine acetyltransferase, or the Crat protein.
Total neuron and choline acetyltransferase - immunoreactive axon length densities for select regions within the striatum and globus pallidus.
To explore this potential, the present study investigated the neurotrophic effects of CTPB (N -(4 - chloro -3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide), which is a potent small molecule activator of the histone acetyltransferase p300 / CBP, in the SH - SY5Y neuronal cell line.
The p300 protein, along with its close cousin CBP, is part of a family of molecules called histone acetyltransferases (HATs).
The team identified three related genes encoding the enzyme, called glyphosate N - acetyltransferase (GAT).
The lower level of spermine in the epileptic rat's brain was evidently caused by an upregulation of spermidine / spermine - N (1)- acetyltransferase.
Mutations of histone acetylation genes (category II) were found in EP300 (encoding H3K18 acetyltransferase, 10/125 patients, 8.0 %) and in CREBBP (encoding H3K18 acetyltransferase, 5/125 patients, 4.0 %).
The catalytic core of p300 shown here has a domain that acetylates chromatin (histone acetyltransferase or HAT) and a domain that recognizes the acetylation (bromodomain or Bd).
Total neuron and length densities of tyrosine hydroxylase (TH), choline acetyltransferase (ChAT), and serotonin transporter (SERT)- immunoreactive axons in the frontal cortex (areas 4, 9, and 32) of humans, chimpanzees, and moor macaques.
Serotonin N - acetyltransferase (Aanat) as a candidate gene for mouse baseline locomotor activity measured in the home cage Lin Liu, King's College London, UK
Together, Myc and Gcn5, a histone acetyltransferase, reprogram fibroblasts to a stem cell state by activating an alternative splicing network.
In addition, Vitamin D enhances the activity of the enzyme, choline acetyltransferase.