Latent autoimmune diabetes mellitus in adults (LADA): the role of antibodies to
glutamic acid decarboxylase in diagnosis and prediction of insulin dependency
Li, Bennett and Fouad found that the AADC (Aromatic l -
amino acid decarboxylase) enzyme that converts dietary amino acids into trace amines was upregulated in specialized cells called pericytes that wrap capillaries.
In an earlier section we discussed how the body converts glutamine to GABA using the glutamic
acid decarboxylase enzyme and the activated form of vitamin B6.
The autoantibodies commonly produced by people with APECED include one that is a marker of type 1 diabetes, called glutamic
acid decarboxylase autoantibody (GAD).
Evaluation of the use of
malic acid decarboxylase - deficient starter culture in NaCl - free cucumber fermentations to reduce bloater incidence — Y. Zhai, Journal of Applied Microbiology
The endogenous synthesis of taurine is limited by the low activities of cysteine dioxygenase and cysteinesulphinic acid decarboxylase
Patients with LADA — a form of autoimmune type 1 diabetes in adulthood — can be distinguished from patients with non-autoimmune type 2 diabetes by means of the antibody reaction affinity to the enzyme glutamic
acid decarboxylase (GAD).
A targeting vector was designed to insert an internal ribosome entry site (IRES), a Cre recombinase sequence, a polyA sequence, and an frt - flanked neo cassette into the 3» untranslated region (after the translational termination site) of the glutamic
acid decarboxylase 2 locus (Gad2) on chromosome 2.
This is a survey of the distribution, form, and proportion of neurons immunoreactive for gamma - aminobutyric acid (GABA) or glutamic
acid decarboxylase (GAD) in cat primary auditory cortex (AI).
Catecholaminergic neurons containing GABA - like and / or glutamic
acid decarboxylase - like immunoreactivities in various brain regions of the rat
Kosaka T, Kosaka K, Hataguchi Y, Nagatsu I, Wu JY, Ottersen OP, Storm - Mathisen J, Hama K (1987) Catecholaminergic neurons containing GABA - like and / or glutamic
acid decarboxylase - like immunoreactivities in various brain regions of the rat Exp Brain Res, 66 (1), 191 - 210 PubMed 2884126
In Stiff Person Syndrome, which is a rare autoimmune disease in the central nervous system with autoantibodies targeting glutamic
acid decarboxylase (GAD65), the humoral autoimmune response was shown to consist of a Rituximab - sensitive part rapidly cleared after treatment, and a Rituximab - resistant part from long - lived and persistent plasma cells acting as a reservoir for secretion of autoantibodies.
Additionally, if an individual has glutamic
acid decarboxylase (an enzyme) antibodies, the body destroys the enzyme that converts glutamic acid to GABA.
Additionally, some people have antibodies against the glutamic
acid decarboxylase (GAD) enzyme, which is involved in the release of insulin from the pancreas.
Although larger studies are needed, this deficiency in glutamic
acid decarboxylase could be explained by the presence of antibodies against glutamic acid decarboxylase 65 (GAD65) which has been detected in the serum of children with autism [12].
Moreover, children with autism are also deficient in glutamic
acid decarboxylase, an enzyme involved in converting glutamate to GABA (γ - Aminobutyric acid).
GAD stands for glutamic
acid decarboxylase, an enzyme that triggers production of the brain's primary calming chemical, called GABA.
Testing for antibodies against glutamic
acid decarboxylase and antinuclear antibodies was negative.
Recently, a radioimmunoprecipitation assay was developed to detect antibodies to recombinant canine glutamic
acid decarboxylase and insulinoma antigen - 2 (84,85).
Maternal care and DNA methylation of a glutamic
acid decarboxylase 1 promoter in rat hippocampus
Phrases with «acid decarboxylase»