Sentences with phrase «activation of genes»

Goats as Drug Factories Initially, GTC generated transgenic goats by microinjecting into the developing nucleus of a one - cell embryo a gene encoding the desired human protein (along with DNA that promotes activation of that gene in milk).

In bacteria, the ligand - PBP complex develops high affinity for transmembrane proteins such as Trg, and the chimeric Trg - HK protein allows activation of gene expression with one additional protein, a bacterial response regulator [5].

The analysis also showed that the preponderance of host responses shifted rapidly from activation of genes involved in cell damage and inflammation toward those linked to promotion of cellular and organ repair.

Genetic analysis of the same tissue regions revealed higher activation of genes associated with vascularization and altered metabolic states.

These patients typically are treated with drugs that inhibit activation of the gene, but nearly all tumors eventually develop resistance to these therapeutic agents.

Activation of the genes enlarged the artery to restore blood flow and mitigated the blood vessel injury that follows blood flow pattern changes.

The researchers tested whether HDACis, which promote long - lasting activation of genes involved in learning and memory, could help replace old traumatic memories with new memories.

Activation of a gene induces a cell to make an RNA copy of its code, edit unneeded segments out of that message, and splice together a final version of the message that provides cellular factories (ribosomes) with a template to make one specific protein.

With most research like this, scientists lower protein levels by suppressing activation of the genes that make the protein — which takes time and doesn't necessarily fully eliminate the protein's presence.

The features include genetic insulators to block activation of genes adjacent to the IL2RG DNA insertion site.

This prevents activation of genes, so this is therefore an exclusion type regulation where insulin signaling leads to prevention of gene activation by Fox01.

Activators of histone acetyltransferases (HAT) provide an alternative approach for the selective activation of gene expression, however little is known about the potential of HAT activators as drug therapies for PD.

In mice that gorged and then fasted, the researchers saw elevations in inflammation, higher activation of genes that promote storage of fatty molecules and plumper fat cells — especially in the abdominal area — compared to the mice that nibbled all day.

Trithorax - like group complex containing KDM6A acts antagonistically to Polycomb - repressive complex 2 (PRC2) containing EZH2 in maintaining the dynamics of the repression and activation of gene expression through H3K27 methylation.

Additionally, turmeric has been shown to act on the liver to regulate epigenetic (activation of genes) and enzymatic factors that all work together to stabilize blood sugar and triglyceride levels in people with diabetes.

This action can result in the activation of genes that had been switched off, and could be the cause of the recovery of synaptic strength.

This can complicate or facilitate the activation of a gene.

The cellular functions that Finch studied for his «second Ph.D.» included the activation of the gene that encodes tyrosine aminotransferase (TAT).

This triggers the activation of a gene that protects cells from dying, making cells virtually immortal — the hallmark of a tumor.

The researchers analyzed videos of Drosophila fly embryos undergoing DNA transcription, the first step in the activation of genes to make proteins.

«The routine capture of single cells and accurate sampling of their molecular features now is possible,» said Alex Pollen, PhD, who along with fellow Kriegstein - lab postdoctoral fellow Tomasz Nowakowski, PhD, conducted the key experiments, in which they analyzed the activation of genes in 301 cells from across the developing human brain.

VY: A lot of biology is dictated by the timing and location of the activation of genes.

«These findings suggest that EBV infection in cells can actually drive the activation of these genes and contribute to an individual's risk of developing the disease.»

«We generated DNA sequences consisting of the gene, either MIZ1 or SnRK2.2, with different «switches» to control the activation of the gene in specific layers of the root,» Nottingham's Daniela Dietrich explains to New Atlas.

Using the well - characterized signaling pathway of the phytohormone ethylene and plant - optimized genome - wide ribosome footprinting, we have uncovered a molecular mechanism linking this hormone's perception to the activation of a gene - specific translational control mechanism.

Turning this receptor on will cause the activation of genes which increase fat burning and reduce the storage of additional fat.

The goal in this service is to determine your genetic weaknesses and focus on prevention and reversal of the activation of these genes by «epigenetic» measures.