Sentences with phrase «adenosine deaminase»

In another landmark success, scientists in Italy and the United States cured «bubble» babies who have a malfunctioning gene for the enzyme adenosine deaminase, which causes a buildup of toxic products that destroy immune cells.

Babies born with the defect are unable to produce an enzyme called adenosine deaminase (ADA).

We also investigate the biological role of adenosine deaminases of tRNAs (ADATs).

This A-to-I RNA editing is catalyzed by members of the ADAR (adenosine deaminases acting on RNA) gene family, discovered in the lab.

This is in addition to the licensing of products such as GlaxoSmithKline's Strimvelis ex-vivo stem - cell therapy for treatment of severe combined immunodeficiency caused by adenosine deaminase deficiency (ADA - SCID) in 2016 (1)-- has led to an increase in demand for therapeutic vector manufacturing capabilities.

Liu and coworkers solved that problem by using directed evolution and enzyme engineering to convert a bacterial adenosine deaminase that normally works in RNA into a deoxyadenosine deaminase that converts A to inosine (I) in DNA.

SR - TIGET was one of the pioneer institute bringing hematopoietic stem / progenitor cell (HSPC) gene therapy (GT) from preclinical studies to successful clinical applications in adenosine deaminase (ADA)- deficient severe combined immunodeficiency (SCID) and Wiskott - Aldrich syndrome (WAS).

The assay mixtures were prepared in 25 mM potassium phosphate buffer pH 7.5, 1 mM EDTA, 2 mM MgCl2, 0.01 % Triton X-100 with 5 µM SAHH, 0.3 U / ml of adenosine deaminase from Sigma, 25 µM SAM, and 15 µM Thioglo - 1.

In this assay SAHH (S - adenosylhomocysteine hydrolase) and adenosine deaminase convert the methyltransferase reaction product (S - adenosylhomocysteine) to homocysteine and inosine.

The drug, an enzyme called adenosine deaminase, or ADA, ultimately may be able to activate the immune system against HIV and to help the immune system «remember» the virus to prevent or quickly eliminate future infection.

She characterized a family of enzymes called ADAR (adenosine deaminase acting on RNA) that are responsible for RNA editing.

There are many causes of this disorder; in Katlyn's case it was lack of the enzyme adenosine deaminase, or ADA, which rids the body of a natural toxin called deoxyadenosine.

C. elegans is a microscopic worm that like humans highly expresses a family of proteins in the nervous system called ADARs — adenosine deaminases that act on RNA — a family that includes ADR - 1.

The anomaly leaves sufferers without an enzyme, adenosine deaminase (ADA), and the resulting buildup of toxins prevents the T cells of the immune system from maturing.

«Adenosine deaminase may help the immune system fight HIV on its own: Adenosine deaminase enhances anti-HIV-1 specific immune responses by reducing the action of cells that impede HIV - specific defenses.»

One type of immune deficiency in humans is caused by deficiency of an enzyme called adenosine deaminase, or ADA.