Associate Professor Djordjevic said that even with appropriate treatment, high mortalities are reported highlighting the need to develop more
effective antifungal therapies.
Although Inz - 1's therapeutic promise is limited by its poor stability in animals, the compound proves that conserved cellular processes can be viable targets for selective antifungal therapeutics and could provide targets for effective
combination antifungal therapy.
Despite extensive and repeated diagnostic testing as well
as antifungal therapies, he continued to have resistant nasal fungal infections, and even developed liver toxicity from one of the antifungal drugs.
Updating the 2008 guidelines, the new guidelines for the diagnosis and treatment of aspergillosis highlight the increased evidence for
antifungal therapy recommendations as well as diagnostic tests.
«Having this gene variant and low ASCA titers could be a good indicator that a Crohn's disease patient might benefit
from antifungal therapy,» Dr. Iliev said.
In advanced cases where there are multiple or diffuse ringworm lesions, it is necessary to usually combined a good antifungal shampoo with any of the primary antifungal ingredients listed for topical treatment in the previous paragraph, combined with
oral antifungal therapy.
Treatment with fluconazole effectively clears infection caused by this mutant, indicating that
combination antifungal therapy could be highly effective when one of the agents targets mitochondrial respiration.
Our group is working to identify how this fungus invades human tissues in order to develop new, more
effective antifungal therapies to prevent and cure this aggressive and common condition.
The findings suggest that patients receiving
the antifungal therapy may be functionally immunocompromised and more vulnerable to influenza and other viral infections, the researchers said.
We are interested in the mechanistic function and structure of antimicrobial / antifungal proteins and peptides and the identification of target molecules for the development of new antimicrobial /
antifungal therapies.
An effective
antifungal therapy may significantly retard cancer progression.