Sentences with word «aptamer»

Its interior is lined with a series of gold electrodes, each dotted with thousands of identical short strands of DNA called aptamers.

Chemistry: Selection of a DNA aptamer for homocysteine using systematic evolution of ligands by exponential enrichment

Eva Klopf and colleagues demonstrate that RNA polymerase - binding Aptamers represent a novel type of regulatory RNA signal in Saccharomyces cerevisiae

We have successfully evolved families of aptamers targeting the HIV envelope that neutralize HIV infectivity, yet can be internalized in HIV infected cells to deliver therapeutic siRNAs.

In fact, the mice that received the complete nanomedicine package had smaller tumors and longer lifespans than their counterparts injected with saline, nanoparticles without the drug, the drug alone, and nanoparticles with the drug but without the targeting aptamers.

Estrogen molecules caught by the longer aptamer are likely held above the bilayer, and so do not create the electrical signal.

Finally, the laboratory has been actively using an in vitro evolution process (SELEX) to evolve RNA aptamers for use as therapeutics but also to serve as siRNA delivery vehicles.

Treating a human disease with aptamers is still «a leap, but in principle we can do this,» says Smith.

Estrogen molecules that are caught by the short aptamer disrupt this layer, which in turn changes the current through the device.

And because aptamers are easily synthesized by machine, Smith says they may be cheaper and easier to make than drugs produced by cell culture.

«We gave huge amounts of aptamer over six months», yet there were no signs that the compound was unsafe, he says.

The problem seems to be confined to this particular compound, but nonetheless, the company has shifted its focus away from aptamers.

Their sensor would expose samples to all those random aptamers, garnering information from each hit.

Szostak's work with synthetic aptamers and ribozymes has convinced him that RNA could have once dominated the world.

Unlike aptamers, which are capable only of sticking to something else, ribozymes can change the structure of other molecules.

Aptamers turned out to be capable of performing an extraordinary range of tasks.

They say that the system can be constructed with more than five different aptamers, allowing detection of multiple biomarkers at once.

The team demonstrated that their system can work by testing three aptamers on one DNA backbone.

If a sample contains gluten, the substance can bind to one of three capture agents, which can be antibodies or a DNA - based aptamer, that specifically latch onto gluten proteins from certain sources.

Losick is using this year's winning Ph.D. dance — a Scottish folk dance version of directed DNA aptamer evolution — as a teaching tool in his classes.

Aptamers offer advantages over antibodies as they can be engineered completely in a test tube, are readily produced by chemical synthesis

More information: Maryna Perepelyuk et al, Evaluation of MUC1 - Aptamer Functionalized Hybrid Nanoparticles for Targeted Delivery of miRNA - 29b to Nonsmall Cell Lung Cancer, Molecular Pharmaceutics (2018).

Our group seeks to investigate the use of chemically - modified nucleic acid aptamers, single stranded DNA or RNA sequences that specifically bind to a diverse variety of targets, in biosensing and catalysis.

SELEX uses natural selection to find the small strands of DNA called aptamers (the other dancers) that bind specifically to the target.

Plank and her team attached their estrogen - binding aptamers to the other important part of their device: the carbon nanotube thin film field effect transistor (CNT FET).

Plank notes that if water was used in the device, instead of the biologically similar buffer, the long aptamer might also produce a signal because the electrically sensitive layer would be thicker.

This symposium features several topics including extension of the genetic alphabet, selection of aptamers or DNAzymes, as well as studies in DNA and RNA epigenetics.

Indeed, treatment of mice with POSTN specific DNA aptamers, single - stranded DNA oligonucleotides designed to bind and inhibit POSTN, was shown to decrease primary tumor growth and metastasis in a xenograft model of mammary tumorigenesis (Lee et al., 2013).

@Vic — Science has repeated evolution, e.g. SELEX / RNA aptamers, speciation in labs, Lenski's E. coli experiments, artificial selection in domesticated organisms, etc, etc..

The molecule was designed such that the EGFR - targeting component is sandwiched between the HER2 - and HER3 - targeting components in what is known as a HER2 aptamer - EGFR siRNA - HER3 aptamer chimera.

But if a sample is exposed to such an aptamer library, a complex molecule is going to bind with a lot more sequences than a simple one.

Johnson's team borrowed a technique from cancer biology, called the systematic evolution of ligands by exponential enrichment (SELEX), which creates a huge library of random, short chains of nucleotides, called aptamers, and then incubates them with a target of choice, such a specific breast cancer cell.

SELEX is typically repeated multiple times, with scientists filtering out the aptamers that are not specific to their target.

This therapy was an aptamer, a small strand of nucleotides designed to inhibit TFPI's activity by binding to it, much like an antibody.

But the aptamers were designed to bind either to an anticancer drug called doxorubicin or an antibiotic called kanamycin.

In it, a continuous stream of a buffer solution flows next to the aptamer - coated electrodes.

A chemical group at one end anchors each aptamer to the gold electrode.

When they do, the aptamers curl around the drug and pull the redox reporter close enough to the electrode for the electrons to hop over and produce a rise in the electric current, signaling the presence of the drug.

Only the drug molecules are small and fleet enough to diffuse through the buffer and get snagged by the aptamers.

«Aptamers are a potentially powerful tool for sensors because they are so versatile and selective,» said Natalie Plank, a researcher who studies nanomaterial device fabrication at the Victoria University of Wellington.

The beauty of the aptamer plus CNT FET sensors is that the aptamers can be easily replaced with new ones that target a different molecule, Plank said.

Aptamers are developed through a process similar to natural selection.

Once the researchers attached the aptamers to the carbon nanotubes, they tested the devices in a buffer specifically chosen because it has similar properties to biological fluids.