Sentences with phrase «axon growth»

In marked contrast, human glial precursor cells and astrocytes generated from these cells by exposure to ciliary neurotrophic factor both failed to promote significant behavioral recovery or similarly robust neuronal survival and support of axon growth at sites of injury.

«Most previous scaffolds have supported axon growth into the scaffold but not out again.

Because a protein in mammalian myelin called Nogo - A is known to inhibit central nervous system axon growth in mammals, a team of researchers led by biologist Claudia Stürmer at the University of Konstanz in Germany wondered if fish might be missing this protein.

We will leverage state - of - the - art bioinformatic and biological approaches for investigating how these factors interact in combination to regulate axon growth during RGC development and test the potential of such factors for regenerating RGC axons in a rodent model of optic nerve injury.

Our approach is innovative in that we propose to study a novel group of bioinformatically - predicted factors, which we hypothesize cooperate in controlling RGC axon growth and regeneration.

Using a technique called diffusion tensor imaging, which can spot neural connections, the researchers saw what appeared to be massive tracts of new axon growth.

Injections of the drug under the skin of paralyzed rats near the injury site partially restored axon growth and improved movements and bladder functions.

Treatment with ISP freed axon growth.

Initially, the goal of the study was to understand how interactions between PTP sigma and chondroitin sulfate proteoglycans prevent axon growth.

Eager to establish himself, he chose a natural extension of the work he did with Tessier - Lavigne: identifying the molecular cues that guide axon growth toward and away from the brain.

My lab is investigating the normal cellular functions of signaling pathways implicated in neurological disease, with an emphasis on axon growth and guidance.

These and other differences between hGDAsBMP and undifferentiated hGPCs and hGDAsCNTF, such as the marked differences in expression of axon growth inhibitory CSPGs and the expression of GDNF, may all contribute to creating a particularly effective cell type for promoting functional recovery in the traumatically injured adult central nervous system.

She is a recognized leader in the field, especially for her use of in vivo imaging methods to study the mechanisms controlling neuronal axon growth.

Researchers hope to prevent expression of molecules that suppress axon growth using molecular biology techniques.

His laboratory at Stanford University School of Medicine is developing novel stem cell and nanotherapeutics approaches for ocular repair, studying retinal ganglion cell development, survival and axon regeneration in glaucoma, and investigating the cellular basis for the developmental loss of axon growth ability.

Tessier - Lavigne studies the molecular signals that provide directional guidance to axon growth in mice and rats.

During his doctoral and post-doctoral work under the mentorship of Jeffrey Goldberg, MD, PhD, and Larry Benowitz, PhD, Dr. Trakhtenberg discovered (1) how Set - β and PP2A proteins regulate axon growth; (2) the role of serotonin receptor 2C in neurite growth and processing of visual information; and (3) that inhibiting the transcription factor Klf9 acts synergistically with zinc chelation in stimulating axon regeneration.

The team also performed a biochemical screen to identify molecules expressed in scar tissue and discovered relatively high levels of factors that support axon growth.

The scientific knowledge gained from this research could be paradigm - shifting for understanding the regulation of axon growth and regeneration in the CNS.

To investigate this, we are characterizing the role of the SMN protein in axon growth and guidance in vivo, as well as identifying proteins and mRNA targets that interact with SMN in neurons.

Figure summarizing the three major steps of axon development in the CNS: axon specification during neuronal polarization, axon growth and guidance, axon branching and presynaptic development (Modified from Lewis, Courchet and Polleux, The Journal of Cell Biology, 2013).

Cell 2007), axon growth and branching (Courchet, Lewis et al..

hGDAsBMP provided extensive benefit, including robust protection of spinal cord neurons, increased support of axon growth and locomotor recovery.