Sentences with phrase «blood vessel cells»

Once the sensors have traveled into a tumor's leaky blood vessels, they use special targeting molecules to bind to receptors on the surface of blood vessel cells.

When the team tested the drug on cells grown in the lab, they found that it killed blood vessel cells and prevented growth of new blood vessels.

These genes and proteins are found in cancer cells or in cells related to cancer growth, like blood vessel cells.

LDL - low density lipoprotein, which in its dense form can lodge in blood vessel cell walls causing blockage if it is too plentiful.

Breast cancer tumors can fuse with blood vessel cells, allowing clumps of cancer cells to break away from the main tumor and ride the bloodstream to other locations in the body, suggests preliminary research.

For a proof of principle test, Deosarkar grew the rat brain blood vessel cells on the vascular side of the chip and tested the barrier they formed under a variety of flow conditions with a range of tests including immunofluorescence staining of tight junctions that interconnected the endothelial cells as well as the electrical resistance across the barrier, and by tracking various sized molecules as they crossed to the tissue side of the model.

It may even be possible to modify the cancer blood vessel cells to secrete factors that would inhibit cancer cell growth.

«Loophole for cancer cells found: Cancer cells kill blood vessel cells so that they can slip through the vascular wall, form metastases.»

After 12 weeks, the explanted constructs matured and showed no malignancies but complete maturation of bone tissue, while blood vessel cells began to integrate along the grafts.

Blood vessel cells activate a series of proteins that switch on apoptosis (programmed cell death) in order to self - renew.

As part of the body's normal, healthy immune response to infection, the barrier formed by blood vessel cells temporarily loosens, allowing white blood cells to exit the bloodstream and attack the invading bacteria or virus, Rehman said.

In lab experiments with human lung blood vessel cells, the researchers found that low - oxygen conditions induced the expression of the oxygen - sensitive gene regulator HIF2alpha, which in turn increased levels of VE - PTP.

Because the toxin does not target the tumor cells themselves but rather the host - derived blood vessel cells, the strategy could be efficacious for a wide range of tumor types, the NIH team notes.

A switch has been discovered that instructs blood vessel cells to become blood stem cells during embryonic development in mice.

A team at the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS) and the Wyss Institute for Biologically Inspired Engineering at Harvard University has invented a method for 3D bioprinting thick vascularized tissue constructs composed of human stem cells, extracellular matrix, and circulatory channels lined with endothelial blood vessel cells.

It has two compartments, one to grow blood vessel cells in and another for cultured brain cells, mimicking the physiology of the BBB.

We found that it is very selective and potent at stopping the growth of blood vessel cells without having negative effects on the growth of other cell types from the eye and elsewhere in the body.

This is basically tweaking the molecules: making small chemical changes to the compound in hopes of finding something that could block the growth of blood vessel cells initially in the culture dish without having toxic effects on other cell types.

You may also find cancerous cells in the red blood vessel cells and the lymphatic area.

Described in a paper published today in the Journal of Clinical Investigation, the treatment would use a patient's own cells, modified to lower production of a protein called protein kinase C delta (PKC - delta), which the scientists implicated in the slow formation of blood vessel cells in diabetic wounds.

The trophoblasts along with blood vessel cells were added to small dextran beads that were then spun around in a container filled with cell culture fluid, creating shear stress and rotational forces to better mimic the environment at the maternal - fetal interface than static cell - culture systems.

Two leading causes of blindness can be reversed or even prevented by drugs that activate a protein found in blood vessel cells.

Moreover, whereas the blood vessel cells that resulted could also form capillarylike structures, they and the retinal cells aged prematurely, losing their ability to divide.

Tissue or adult stem cells — «blank» cells that can act as a repair kit for the body by replacing damaged tissue — encourage the regeneration of blood vessel cells and new heart muscle tissue.

«In a healthy immune system, one of CD11b's normal jobs is to make specific leukocytes adhere to the surface of blood vessel cells,» Ubogu said.

As a result, the macrophages can eat the glucose instead of the blood vessel cells.

They found that besides traveling in the bloodstream, melanoma cells could also move along the abluminal, or outside, surface of blood vessels by way of angiotropism, a biological interaction between the cancer cells and the blood vessel cells.

In addition to cardiac cells, Petzold and Aigner attempted to apply other cells, such as connective tissue cells and blood vessel cells, to the film, and were successful each time.

«The nanoparticles do not need to cross the blood - brain barrier as they were specifically designed to target the blood vessel cells within the tumor,» explains radiologist Brian Ross, one of the study's authors.

The answer was yes: They found cells with markers from all three major body cell types, called germ layers: ectoderm (such as nerve cells), mesoderm (muscle and blood vessel cells), and endoderm (kidney cells).

«It seems that the blood vessel cells have their own way of tightening up the barrier when they are in a low oxygen stress situation.»

They found that blood vessel cells were not the ones making the openings, as previously thought.

Tumors, for example, send growth signals to blood vessel cells to keep them growing and thus secure the blood supply to the tumor.

Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.

We really wanted to find a compound, a chemical, that would profoundly stop the growth of blood vessel cells, which of course are the cells that go on to form the abnormal angiogenesis in wet AMD.

TSAd coordinates the reaction in the blood vessel cell's contact with the surrounding.

We came across a compound that had been isolated from a plant species and shown to have effects on blocking the growth of blood vessel cells, both in the culture dish and also in animal models.

The researchers found that, when stimulated by insulin, diabetic fibroblasts produced less of the VEGF (vascular endothelial growth factor) signaling protein, a key player in boosting the growth of blood vessel cells, than normal fibroblasts did.

In the present study the researchers show how leakage arises through a reaction where VEGF and various other proteins in the blood vessel cell interact, with the result that the cell looses contact with its neighbouring cells.

It interacts with the blood vessel cells and basically tells them to grow.

Because, of course, it is this abnormal proliferation of blood vessel cells, which we term angiogenesis, in the back of the eye that is the key feature of wet AMD.

They identified 47 different kinds of cell, including a large proportion of specialised neurons, some blood vessel cells and glial cells, which take care of waste products, protect against infection and supply nerve cells with nutrients.

extremely good for your heart health — thanks to its rich beta carotene which is converted into super antioxidant Vitamin A — which protects the lining of blood vessel cells and prevents free radicals from oxidizing cholesterol in the bloodstream.

These have an anti-inflammatory effect on blood vessel cells and have been shown to decrease the risk of heart attack.

Additionally, the rapid metabolism of fructose in the liver and resultant drop in ATP levels have been linked with mitochondrial (energy) and endothelial (blood vessel cells) dysfunction, alterations that could predispose to obesity, diabetes, and hypertension.

Hemangiosarcoma in dogs is an aggressive, malignant tumor of blood vessel cells.

They can also suffer from hemangiosarcoma, a tumor of blood vessel cells.