Hellmut Augustin's team at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the University Medical Faculty Mannheim of Heidelberg University has now discovered a new mechanism that promotes the growth
of blood vessels in tumors.
In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the
abnormal blood vessels in the tumor,» says Patrizia Agostinis.
Barenholz's nanoparticles generally stayed in the bloodstream and avoided the heart and other organs, but when they reached the
leaky blood vessels in the tumor, they slipped through those holes.
Earlier studies by Basu and others have shown that dopamine blocks the growth of new
blood vessels in tumors by inhibiting the action of vascular endothelial growth factor - A (VEGF - A).
Recent studies have shown that curcumin can reduce growth of
new blood vessels in tumors and metastasis and basically help kill off cancerous cells.
However, when these myeloid cells migrate to tumor sites, they can differentiate to tumor associated macrophages (TAMs), which can in turn stimulate the formation
of blood vessels in tumors and promote enhanced tumor cell invasion and motility.
A new study led by scientists at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) suggests that dopamine — an inexpensive drug currently used to treat heart, vascular and kidney disorders — can be safely used in cancer treatment to curb the growth of
blood vessels in tumors.
VEGF normally promotes the growth of endothelial cells, which in turn helps build new
blood vessels in tumors.