Sentences with phrase «breast tumours»

The manufacturer states in its literature that chronic treatment with domperidone in rodents has resulted in increased numbers of breast tumours in the rodents.

D - Limonene — Suppresses * tumours, reduces * tumour size, prevention of mammary, liver, lung and other cancers [5], carcinogen removal, reduction * in breast tumour growth [6], inhibition of mammary carcinomas [7], breast carcinoma regression in both early and late stage development [8].

As yet, mutations in BRCA1 have not been linked to sporadic breast tumours.

«The new discovery has given us an important link between the biochemical function of PTEN and its role in prostate cancer, and in some triple negative breast tumours for which treatment is currently limited.»

When breast tumour cells develop in reaction to MPA, they promote the formation of new blood vessels inside tumours, which then supply necessary nutrients for the growth and multiplication of tumours.

PyMT - Tg female mice on Slc6a14 + / + and Slc6a14 − / − backgrounds were monitored for breast tumour development.

Green Tea — Acts to inhibit breast tumour growth, improves * liver detoxification of estrogen [1], reduces * aromatase and lowers levels of damaging oestrogens, protects against oestrogen - specific free radicals and carcinogens

TNBC is deadly because, unlike other types of breast cancers such as estrogen receptor (ER) positive or HER2 amplified breast tumours which have effective targeted therapy, TNBC tumours do not respond to targeted therapy.

When Victorian doctors tried to spot breast tumours using candlelight, it didn't work.

The control group without the vaccination developed breast tumours.

Inside many breast tumours are tiny granules of calcium.

They gave the glowing version of the drug to a woman about to have her primary breast tumour surgically removed.

To make the process generic, his team is using techniques developed to identify breast tumours.

Now, the researchers have discovered an alternative in a mouse model: in the case of breast tumours with a specific defect in DNA repair, the animals can be cured using already established, cheap chemotherapy drugs, if enough DNA damage can be inflicted on the resting tumour cells.

The prospect of identifying women with a particularly high risk of developing inherited forms of breast cancer arose last autumn, when researchers in the US finally tracked down a gene known as BRCA1, which in mutated form is responsible for about half of all inherited breast tumours.

THE Pentagon is turning its attention from the war on communism to the war on cancer by adapting military technologies to detect breast tumours.

The team found that most of the genetic changes in the original breast tumour were also present in the metastatic tumours, showing that the cancer cells spread late in disease development.

Dr Gathani said: «Much of the apparent excess of aggressive breast tumours in South Asian and Black women is simply because they are younger than White women.

In 30 percent of human breast tumours, this growth factor is much more abundant in the membrane than in healthy cells.

The rodents experienced hormone imbalances and more and bigger breast tumours, earlier in life, than rats fed a non-GM diet, the researchers claim.

Due to close similarities of the growth factor in humans and dogs, also a treatment of canine breast tumours seems possible.

Tom Sanders, head of nutritional research at King's College London, says that the strain of rat the French team used gets breast tumours easily, especially when given unlimited food, or maize contaminated by a common fungus that causes hormone imbalance, or just allowed to age.

Early breast tumours show up on a mammogram long before they can be felt as a lump.

Women who were morbidly obese - those with a body mass index of 35 or above - had a 58 per cent higher risk of developing an invasive breast tumour than women who were a healthy weight.

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups Nature DOI: 10.1038 / nature10983

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution Nature, 461 (7265), 809 - 813 DOI: 10.1038 / nature08489

ab16056 staining COX IV in breast tumour tissue sections by Immunohistochemistry (IHC - P - paraformaldehyde - fixed, paraffin - embedded sections).

The group went on to identify three key signalling networks that were represented by the bCSC DMR - associated genes; NFKB RB1 and TGFB1, and then analysed these networks in various breast tumours.

Furthermore, the growth of PyMT - driven breast tumours was markedly reduced on Slc6a14 − / − background compared with Slc6a14 + / + background (Figure 2C).

We examined the expression of Slc6a14 in breast tumours obtained from 4 - month - old PyMT - Tg female mice and in mammary glands obtained from age - matched wild - type female mice.

To establish unequivocally the tumour - promoting role of SLC6A14, we generated a mouse line with the deletion of the gene coding for the transporter, characterized the phenotype of Slc6a14 - null mice and examined the impact of the transporter deletion on breast tumour in two different mouse models of spontaneous breast cancer.

This is a benign breast tumour, which is painless and slow - growing.

The most infamous study on parabens ever conducted was in 2004; it revealed that 99 % of all female breast tumours (out of 160 sampled) contained synthetic parabens.

Cheng C, Edin NF, Lauritzen KH, Aspmodal I, Christoffersen S, Jian L, Rasmussen LJ, Pettersen EO, Xiaoqun G, Bergersen LH (2012) Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells Cell Oncol (Dordr), 35 (3), 217 - 27 PubMed 22700320

Intriguingly, previous research found that RASAL2 was lost in some of the luminal type of breast tumours, where it acts as a tumour suppressor.

Each gene in the region is being studied to see whether it is abnormal in breast tumours.

Because her tumour cells had tested positive for oestrogen receptors, she was also put on tamoxifen, a drug that blocks the supply of the female sex hormone that triggers some breast tumours to grow.

In addition, they showed for the first time that these genes are often the same as those that are altered in breast tumours - when a tumour develops, the DNA within the cancer cells themselves mutates.

The team has studied the most common kind of breast tumour — estrogen - positive (ER +) and accounting for 80 % of breast cancer tumour cases — that is characterised by a long period of latency with no symptoms.

The findings provide insights into the causes of breast tumours and demonstrate that breast - cancer genomes are highly individual.

Interestingly, the molecular signature of the fibroblasts isolated from high density tissue also matched the fibroblasts found in breast tumours, meaning drugs that interfere with the JNK1 network could also potentially act as a treatment for women who already have breast cancer.

However, the researchers found that breast tumours were still slightly larger in ethnic minority than White women, even after adjustment for age and other potential confounding factors.

The scientists were able to produce mimotopes for the growth factor HER2, a tumour antigen of about 30 percent of breast tumours, without chemical after - treatment at these AAV carrier particles and use them directly as a specific vaccine.

But in the same issue of Nature Genetics (vol 9, p 444), Jeffrey Holt and colleagues at Vanderbilt University in Nashville say they have found the gene to be less active in breast tumours than in normal breast tissue.

And although there is no evidence to suggest that mutant copies of BRCA1 are to blame for sporadic breast tumours, another research team has found that the gene seems to be much less active inside sporadic breast tumours than in healthy breast tissue.

With this finding, RASAL2 could be a new potential biomarker that is associated with the high risk of TNBC, rather than all types of breast tumours.

«Patients» breast tumours can vary significantly in their biology over time.

Dr. Poul Sorensen's team studies a range of childhood cancers as well as a subset of breast tumours.

The rats were exposed to 1 of the chemicals utilized in the most commonly used HRTs in the US — a progestin known as MPA (medroxyprogesterone acetate), which is also the very same synthetic hormone which accelerates development of breast tumours.