Sentences with phrase «calcium sensor»

The size of the otoferlin molecule and its low solubility have made it difficult to study, including how otoferlin works differently than another neuronal calcium sensor in the brain, synaptotagmin.

Nicholas Steinmetz and colleagues found that some mice expressing the genetically - encoded calcium sensor GCaMP6 display brief bursts of electrical activity, commonly observed in epileptic patients and animal models.

Südhof then made use of the emerging power of mouse genetics to delineate the functional role of a number of these vesicle proteins including the role of synaptotagmin, which he demonstrated to be the critical calcium sensor for rapid neurotransmitter release.

To clarify whether CCHa2 directly signals to the brain, calcium imaging was performed using ex vivo culture of larval brains expressing the fluorescent calcium sensor GCaMP6s [31] in the IPCs.

Recent work here at the MRC Centre has shown that a member of the Neuronal Calcium Sensor family of proteins,, provides a link between Ca2 + influx via NMDA receptors and clathrin - mediated internalisation of AMPA receptors (Palmer et al 2005).

These results confirmed the notion that synaptotagmin functions as the calcium sensor.

Synaptotagmin: A calcium sensor on the synaptic vesicle surface.

He studied calmodulin, a calcium sensor in cells that binds with multiple enzymes.

To avoid overlap with this optogenetic tool, they needed to create a calcium sensor with the following characteristics:

He studied functional circuit processing throughout the visual system, including thalamus, primary visual cortex and extrastriate visual areas using in vivo two - photon imaging, calcium sensors and viral tracers.