To address this question, the research teams from Berlin and Würzburg took a closer look at human
colon carcinoma cell lines that innately show high levels of c - MYC.
Consequently, we targeted EZH2 (an H3K27 methylase) and demonstrated that KDM6A - null urothelial
bladder carcinoma cell lines were sensitive to EZH2 inhibition.
The human esophageal squamous
cell carcinoma cell lines KYSE 510 and KYSE 150 were gifts from Dr. Yutaka Shimada (Kyoto University, Kyoto, Japan).
Treatment of the Gb3 - expressing
gastric carcinoma cell line St3051 with STxB coupled to SN38, the active metabolite of the topoisomerase type I inhibitor irinotecan, resulted in > 100-fold increased cytotoxicity, as compared with irinotecan alone.
This was found to cause lysis in
hepatocellular carcinoma cell lines, but not in normal liver cells indicating that further experimental studies on SOCS3 could increase its future applicability as a cancer cell specific anti-cancer agent.59