Sentences with phrase «catalytic efficiency»

The structure reveals key interactions that probably contribute to the high catalytic efficiency of this enzyme relative to other flaviviruses, indicating promising starting points for drug design.

β - Lactamases encoded by reconstructed sequences corresponding to the GNCA node have been previously shown11 to be able to degrade a variety of antibiotics, including penicillin and third - generation antibiotics with efficiencies similar to that of a modern average enzyme (by contrast, the modern TEM - 1 β - lactamase is a specialist enzyme that displays high catalytic efficiency with penicillin and a substantially lower efficiency with third - generation antibiotics).

Efforts to improve catalytic efficiency and co-localization of ribozymes with their targets in mammalian cells are still an ongoing effort in the lab.

Therefore, the ∼ 30-fold range of catalytic efficiency observed suggests long - range communication between residues, a feature that is often linked to conformational dynamics37, 38,39.

The P2 4 - aminomethylphenylalanine moiety of the inhibitor forms a salt - bridge with the nonconserved Asp83 of NS2B; ion - pairing between Asp83 and the P2 residue of the substrate likely accounts for the enzyme's high catalytic efficiency.

Among the features that determine the catalytic efficiency of a nanoparticle is its electrical charge, which is difficult to quantify in technologically relevant systems, where the particles interact with the surfaces of other materials.

Analysis of Zika virus protease bound to a peptidomimetic inhibitor reveals its catalytic efficiency and promise as a drug target.

A TOF can not be used to characterize the catalytic efficiency of a substance in a reaction because it is not characteristic of a substance.

«You need to add energy to improve the catalytic efficiency,» he said.

TOFs are supposed to characterize the catalytic efficiency of a substance.

Indeed, comparison with these previous Kemp eliminase designs (Fig. 6) provides further evidence that the catalytic efficiencies (kcat / KM values) we have generated in the ancestral β - lactamases are indeed substantial and consequential.

The upper end of the range is above the results previously reported using more complex design approaches26, 27 (iterative design and design based on Rosetta), which also involved large numbers of mutations to reach those efficiencies, and it is less than two orders of magnitude below the catalytic efficiency for the best Kemp eliminase reported for to date28 (which is the outcome of 17 rounds of directed evolution from an iterative design background).