The Kops group studies the signaling networks that regulate chromosome segregation, the evolution
of cell division processes and the role of chromosomal instability in cancer.
Widely different programmes have to be sequenced in parallel to produce gametes: «On the one hand, the genetic material of the source cells must be halved in
the cell division process.
Researchers from the Universitat Autònoma de Barcelona (UAB) Department of Cellular Biology, Physiology and Immunology, and the UAB Institute of Biotechnology and Biomedicine, led by Dr Ignasi Roig, discovered that the signalling route — a cascade activation of several molecules — triggered by the ATM protein regulates DNA repair during the production of spermatocytes by meiosis,
the cell division process which yields spermatozoa.
Findings from the study could help improve understanding of the causes of some diseases — including cancer — that are triggered by errors in
the cell division process, the team says.
The telomeres, therefore, become a little bit shorter with
each cell division process.
Bile acids, which are produced naturally in the liver and stored in the gallbladder, support the protein production during
the cell division process.
Both oscillations have their own natural frequency, and, under normal circumstances, these two oscillations are coupled and compromise with each other at a common frequency, which then governs
the cell division process.
«We used a Tobacco plant cell attached with a fluorescent probe to visualize
the cell division process,» says Ueda.
Published in Nature Communications, a study by scientists at the Institute for Research in Biomedicine (IRB Barcelona) headed by ICREA researcher Angel R. Nebreda has reported that the protein RingoA is a key regulator of meiosis —
the cell division process that gives rise to ovules and sperm for sexual reproduction in mammals.
Chemotherapy utilizes chemicals that interfere with
the cell division process - damaging proteins or DNA - so that cancer cells will commit suicide.
The main aim of our research is to understand how
the cell division process gives rise to two genetically identical daughter cells.
In parallel studies, the Orr - Weaver lab has made major advances in deciphering the complex regulatory system that orchestrates meiosis,
the cell division process that creates eggs or sperm.
The cells are the most vulnerable to cancer and other diseases during
the cell division process.