Sentences with phrase «cellular microenvironment»
The phrase "cellular microenvironment" refers to the surroundings or space in which a cell exists. It includes the various factors and conditions that directly affect the cell, such as its neighboring cells, surrounding tissues, and chemical signals present. Essentially, it describes the specific environment that a cell finds itself in, which influences its behavior and function. Full definition
Instead, tumors should be considered complex tissues in which the cancer cells evolve and communicate with the surrounding cellular microenvironment to promote their own survival and dissemination.
sciencemag.org
In a paper in the Journal of Biological Chemistry, Gina Moriarty and colleagues at Rutgers University show that beta - synuclein forms fibrils at mildly acidic pH, suggesting that pH conditions in cellular microenvironments may contribute to beta - synuclein's role in neurodegenerative diseases.
For efficiently studying cell functions, it is essential to reconstruct cellular microenvironments by parallel manipulation of single cells.
Instead, tumors should be considered complex tissues in which the cancer cells communicate with the surrounding cellular microenvironment and evolve traits that promote their own survival.
To date, much of the research on irradiation's effects on the cellular microenvironment has dealt with samples that included cells, obfuscating the irradiation's effect on just the ECM rather than the cell's internal machinery.
«Laminins function as attractive chemical cues for haptotaxis of axonal growth cones,» explains NAIST Prof. Naoyuki Inagaki, whose lab studies how forces are generated in the cellular microenvironment to create directed axonal migration.
Instead, tumors should be considered as complex tissues in which the cancer cells communicate directly and indirectly with the surrounding cellular microenvironment and evolve traits that promote their own survival.
«While genetic mutations are at the root of cancer, a number of studies over the last 10 to 20 years have implicated the cellular microenvironment as playing a key role in promoting or suppressing tumor progression,» says lead author Ovijit Chaudhuri, a former postdoctoral fellow in the Mooney Lab at Harvard who recently joined the mechanical engineering faculty at Stanford University.
The Stowers Institute's Xie Lab has published findings that begin to characterize the poorly understood interaction among stem cells within their cellular microenvironment, called a niche.
The researchers found that loss of collagen VII not only affected the composition of the cellular microenvironment but also led to global changes in cell homeostasis on mRNA and on protein level.
The center is undertaking several projects, including examining colon cancer's cellular microenvironment, reversing the effects of angiogenesis and understanding how genetic changes may make colon cancer cells more aggressive in some individuals and how those changes may be reversed.
Our research aims at identifying the principles of neuronal interactions with signals from the cellular microenvironment and uncovering disease - relevant targets that can be harnessed to drive drug discovery efforts in neurological and age - related neurodegenerative diseases.
Our microfluidic platform delivers precise control over the cellular microenvironment and beneficially through miniaturization, maximizes use of precious limited human cancer samples.
The microfluidic platform delivers precise control over the cellular microenvironment and beneficially through miniaturization, maximizes use of precious limited human cancer samples.