Sentences with phrase «cellular phenotype»
The phrase "cellular phenotype" refers to the observable characteristics or traits of a cell. It refers to what we can see and measure, such as the cell's shape, size, and behavior, that determine its appearance or function. Full definition
She has discovered several novel disease specific cellular phenotypes in their in vitro models, many of them involved in accurate performance of the neural progenitors.
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«It is already known that Rbfox is important for controlling RNA splicing but what is not understood is its contribution to neuronal maturation and which specific cellular phenotypes it controls,» says Dr. Zhang.
Using this approach, researchers can easily generate diseaserelevant isogenic models to determine the impact of correcting or introducing disease - relevant mutations on cellular phenotypes in a tissue - appropriate context.
296/5: 45 Schizophrenia associated variation in DPYSL2 perturbs mTOR signaling and produces cellular phenotypes.
The fundamental question he raises in his research is how lipid signaling regulates gene expression and how a changing extra - and intracellular lipid environment impacts the expression of the genome and contributes to changing cellular phenotypes.
RNAi - mediated silencing of RASSF1A induced epithelial - to - mesenchymal transition (EMT), fomenting a motile and invasive cellular phenotype in vitro and increased metastatic prowess in vivo.
RELA and INCENP silencing both produce distinct cellular phenotypes that are easily detected by the human eye and can be quantified through image analysis software.
The combination of these methods enables complex tissues to be studied by single cell genomics workflows, revealing interrelationships between molecular and cellular phenotypes within tumor microenvironments.
Other flow cytometry applications include: cellular phenotyping by multiparameter cytofluorimetric analysis, sorting of fluorescence protein - tagged cells, assessing apoptosis and cell cycle status, the identification / isolation of stem and cancer stem cells (e.g., marker positive, side - population, etc.) and the deposition of single cells.
Kevin works on developing high - throughput precision genome editing technologies with CRISPR / Cas9 to enable dissecting the genetic architecture underlying complex cellular phenotypes.
The focus of the Mar lab is to understand how variability in gene expression contributes to the regulation of cellular phenotypes.
Studying genetic variation and its effects on cellular phenotypes and observable traits.
The SMDC has allowed Gladstone scientists to design molecules to modulate the functions of proteins or specific cellular phenotypes and, most significantly, screen for drugs that could be used as therapies for disease.
The objective of the research project led by Marko Kallio, Principal Scientist at VTT, was to accelerate the drug development process by identifying new compounds that would possess similar binding properties and cellular phenotype, but a different chemical structure, as the selected drugs in clinical use or investigational compounds in development.
Current explorations into the molecular underpinnings of cell circuitry are leveraging multiple data types including expression profiling and epigenetic analysis leveraging RNA - seq and CHiP - Seq coupled with molecular markers and cellular phenotypes.