Sentences with phrase «central memory»

The ingenol derivative activates a population called central memory cells.

The phenotype of NP cells generated ex vivo (Figure S8) closely resembles that of central memory CD4 + T cells found in vivo, which persist for years in secondary lymphoid organs and can differentiate into effector memory CD4 + T cells [45].

«Previously it was thought that HIV was hiding primarily in central memory T - cells, but our new HIV genetic sequencing test has revealed that the majority of replication - competent virus is actually hiding in effector memory T - cells.

CD8T and NK cell interaction results in an altered phosphorylation of multiple signaling proteins and mitochondrial Ca2 + dynamics, suggesting a cellular remodeling allowing acquisition of NK cell effector / regulatory and T cell central memory phenotypes.

«We found that the effector cells not only have both the T follicular helper cells and central memory profiles, but they also expressed receptors for two different proteins — interleukin - 6 and interleukin - 7,» Oestreich said.

Elite controllers with low to absent effector CD8 + T cell responses maintain highly functional, broadly directed central memory responses.

Sorting of CD8 + cell subsets (bulk versus central memory) was useless.

CD8 T cells specific for the noninflationary M45 epitope displayed a classic central memory phenotype, re-expressing the lymph node homing receptor CD62L and homeostatic cytokine receptors for IL - 7 and IL - 15, and produced low levels of IL - 2.

After the infection, cell numbers diminish, but central memory T cells retain a long - term ability to defend against reinfection by microorganisms that carry the same antigen.

«Central memory cells allow for such a quick response to antigens that infection typically doesn't have a chance to form.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

In HIV infection, however, a T cell subtype called the central memory CD4 + T cell appears to enter the cell cycle and undergo apoptosis — cellular suicide — in vast numbers.

However, City of Hope researchers are testing an immunotherapy treatment with a specific lymphocyte, called a central memory T cell, that may potentially provide lifetime immunity.