It is approved by the U.S. Food and Drug Administration (FDA) for
treating certain types of leukemia and is helpful in other conditions that require immunosuppressive therapy.
Half of the patients treated in this study responded to either ponatinib (typically used
for certain types of leukemia) or pazopinib (a kidney cancer drug), depending on the genetic alterations identified through sequencing.
Researchers from Instituto de Medicina Molecular (iMM) João Lobo Antunes have found a mechanism through
which certain types of leukemia resist chemotherapy, thus revealing novel molecular targets that may be used to improve the efficiency of this type of treatment.
A class of therapeutic drugs known as protein kinase inhibitors has in the past decade become a powerful weapon in the fight against various life - threatening diseases,
including certain types of leukemia, lung cancer, kidney cancer and squamous cell cancer of the head and neck.
A CBC may also provide clues about infections and inflammation in the body, parasitic disease, blood clotting abnormalities, and
even certain types of leukemias and cancers.
The researchers at Sandia and the university did molecular computer simulations to predict what mutations would produce that desirable result when introduced into the enzyme - drug L - ASN2, commonly used to
treat certain types of leukemia.
The drugs used, pazopanib (top) and ponatinib, are typically used to treat kidney cancer and
certain types of leukemia, respectively.