Sentences with word «cholesteryl»

Increased SQLE expression promotes the biosynthesis of cholesteryl ester, which induces NAFLD - HCC cell growth.

In these studies, atherosclerosis was associated with the diet - induced enrichment of LDL with cholesteryl oleate.

Suppression of tumor growth by terbinafine is associated with decreased cholesteryl ester concentrations, restoration of PTEN expression, and inhibition of AKT - mTOR, consistent with blockade of SQLE function.

The findings make evacetrapib the third failure in a class of drugs known as cholesteryl ester transfer protein (CETP) inhibitors, which are designed to disrupt the natural process by which HDL cholesterol is converted into LDL cholesterol in the body.

May also affect de novo cholesterol synthesis and HDL - cholesteryl ether uptake (PubMed: 21987372).

Research Interests: cholesteryl ester transfer protein; lipid transfer inhibitor protein; apolipoprotein F; reverse cholesterol transport; LDL; HDL; lipid transport; triglyceride; lipid droplets; fat storage

SQLE exerts its oncogenic effect via its metabolites, cholesteryl ester and nicotinamide adenine dinucleotide phosphate (NADP +).

In addition, hepatic lipidomic analyses revealed decreases in several species of triacylglycerols, phospholipids and cholesteryl esters.

Both ApoC - III — depleted TRLs and ApoC - III — bearing TRLs had equal amounts of TGs, free cholesterol, cholesteryl esters, and [3H] retinol when normalized to protein (Supplemental Figure 7).

Notably, in humans, the risk of stroke has been related to both the saturated and monounsaturated fatty acid content of plasma cholesteryl esters, which further supports the possibility that the dietary intake of these fatty acids may influence CVD risk by altering cholesteryl ester composition (87).