Sentences with phrase «chromatin architecture»

Surprisingly, the researchers found a similar bimodal 3 - dimensional chromatin architecture in the Hoxd gene region in zebrafish embryos.

The lab investigates consequences of epigenetic alterations in neuronal cancers and neurodegenerative diseases using a combination of biochemistry, cell and molecular biology with genome wide approaches to gain mechanistic insight into how chromatin architecture is modified in disease.

We have demonstrated that the regulatory regions of housekeeping and tissue specific genes have differential chromatin architecture with respect to S / MAR binding, nucleosome positioning potential and repetitive sequences.

«This means that these histone modifications might be a way through which the metabolic state of the cell is linked to chromatin architecture.»

It seems like the chromatin architecture is reorganized after fertilization, and that this reorganization happens differentially for the maternal and the paternal genomes,» explained Johanna Gassler, PhD student at IMBA and one of the first authors of the study.

The low availability of starting material made it necessary to develop a new single - nucleus Hi - C (snHi - C) method that made it possible to analyze the chromatin architecture in oocytes and single - cell embryos for the first time.

By controlling the transport of histones to our DNA, TLK and Asf1 ensure that the chromatin architecture and its information are copied correctly during cell division, so that cell identity is maintained,» explains Ilnaz Klimovskaia.

If the chromatin architecture is wrong, it can affect both gene expression as well as the stability of our DNA.