Sentences with word «chromosomal»

In addition to maternal exposure, a father's exposure to some teratogens may increase the risk of miscarriage also by increasing levels of chromosomal abnormalities in the sperm.

Forty - five percent of women over 40 do, usually because of chromosomal abnormalities in their eggs.

Perhaps the most striking feature is the extent to which individual genes and entire blocks of chromosomal regions have been duplicated in the Arabidopsis genome.

Research Paper Constructing a «Chromonome» of Yellowtail (Seriola quinqueradiata) for Comparative Analysis of Chromosomal Rearrangements Junya Kawase, Jun - ya Aoki, Kazuo Araki J. Genomics 2018; 6: 9 - 19.

The CHD1 gene is mutated in 15 - 27 % of all prostate tumors, and such mutations correlate with chromosomal instability and poor prognosis for prostate cancer patients.

Two of the world's largest professional societies of human geneticists have issued a joint position statement on the promise and challenges of non-invasive prenatal testing (NIPT), a new procedure to test blood drawn from pregnant mothers for Down syndrome and other chromosomal disorders in the fetus.

A woman's risk of having a baby with chromosomal abnormalities increases with her age.

The creation of memories in the brain involves addition or removal of methyl groups at precise spots on chromosomal DNA.

It is initiated by chromosomal translocation t (11; 22)(q24; q12), which creates the fusion protein and oncogenic driver EWS / FLI.

Fact: The vast majority of miscarriages are caused by chromosomal abnormalities in the embryo.

In ALK + ALCL, the most common chromosomal aberration involving the ALK locus is the t (2; 5)(p23; q35) resulting in expression of the chimeric nucleophosmin - ALK oncoprotein.

With new advances in genetics and medical techniques it is possible to determine many chromosomal defects in embryo.

From a basic research perspective, we have found the first example of a tumor - initiating mutation that directly affects how cells divide, causing chromosomal instability.

Week 11: Chorionic Villus Sampling (CVS), the diagnostic test for chromosomal disorders such as Down syndrome, is usually performed between weeks 10 and 12.

You'll have blood tests, such as the glucose screening test to check for gestational diabetes, and you'll be offered screening tests or amniocentesis to test for Down syndrome as well as other chromosomal abnormalities, genetic disorders, and neural tube defects.

Other efforts include array - based sequencing - by - hybridization with Callida Genomics, and simultaneous typing of SNPs on chromosomal regions undergoing LOH using customized Affymetrix tag - arrays.

According to Director Jin - Soo Kim, «We used CRISPR RGENs [RNA - guided engineered nucleases] to repair two recurrent, large chromosomal inversions responsible for almost half of all severe hemophilia A cases.»

Of note, more than half of first trimester miscarriages occur because of fetal chromosomal problems.

The American College of Obstetricians and Gynecologists recommends that all women be offered screening or testing for chromosomal conditions during pregnancy.

Though this appears small, he told New Scientist, when the researchers checked back with the donors they found that those with the higher frequencies had children with chromosomal anomalies.

Under the stewardship of Christine Armour, the working group, consisting of members from the CCMG Clinical Practice and Laboratory Practice committees with representatives from the SOGC, have updated the 2001 Canadian guidelines for use of chromosomal microarray analysis (CMA).

These results then prompted the research team to conduct further chromosomal analysis, which confirmed that she had trisomy 22.

To investigate in more detail, researchers from KU Leuven and elsewhere employed in vitro fertilization in cattle as a flexible system to study chromosomal changes in single embryonic cells.

Note that these tests are not necessary for every pregnant woman but only for those who have a history of chromosomal diseases in their families or in the cases where the doctor suspects something to be wrong.

Giacomo Cavalli's crew has therefore proven the existence of Polycomb - mediated stable transgenerational epigenetic inheritance dependent on 3D chromosomal structure.

Tests that your doctor or midwife might order include bloodwork, ultrasounds, chromosomal tests, and other exams and procedures to rule out problems with uterus, cervix and fallopian tubes.

Doctors are allowed to preselect sperm for in vitro fertilization to exclude sperm carrying chromosomal damage.

Grant 1591: Discovery of Genetic Susceptibility Loci in Atopic Dermatitis using a Genome - Wide Association Study in West Highland White Terriers Dr. Natasha J Olby, VetMB PhD Project Goal: This research team will conduct a genome - wide association study of Atopic Dermatitis in Westies to identify chromosomal regions associated with the disease.

Investigators found that known ALL subgroups, which are defined by chromosomal alterations, have unique methylation profiles.

UvrD's job is to unwind these damaged and discarded strands from chromosomal DNA, so that they can be disposed of quickly and the associated repair proteins can go on to catalyze additional rounds of repair.

Down syndrome (DS) is a common chromosomal disorder caused by trisomy of chromosome 21 (HSA21q).

They also included a continuous 390,000 base pair long stretch of genomic Y chromosomal region available in brown, polar and black bear genomes to gain a better understanding of the paternal signature of bear evolution.

Tumorigenesis is a multistep process in which chromosomal instability plays an important role.

In the different cell types, the loops begin and end at different specific chromosomal locations, so each cell line's genome appears to have a unique population of loops.

We generated a high - quality draft genome of the species Coffea canephora, which displays a conserved chromosomal gene order among asterid angiosperms.

The authors also found that the demographic collapse and loss of Y - chromosomal diversity observed within the last 2,300 years was mirrored by a significant accumulation of deleterious mutations in the genome of the horse.

Researchers link slipshod construction of chromosomal termini to unregulated tumor cell proliferation

«This work sheds new light on how blood cancer develops and also provides a new approach that can be used to study chromosomal deletions associated with a variety of human cancers, neurological and developmental diseases.»

Men with a high DNA fragmentation index (DFI) also have more chromosomal breaks, which is linked to lower fertility.

Researchers identified novel chromosomal mutations and described their role in the development of resistance of Escherichia coli (E. coli) to broad - spectrum antibiotic fosfomycin, according to research presented at the 28th...

The HMG box is a structure that contains chromosomal proteins that regulate DNA processes such as transcription, replication, recombination and DNA repair.

The formation of CEB1 G - quadruplexes also stimulates gross chromosomal rearrangements.

According to the researchers, this is the first large - scale study employing epigenome - wide association (EWAS) studies — which look at chromosomal make - up and changes — in relation to the brain and Alzheimer's disease.

Yes, they have new names and faces, but they are running from the same agency, dodging the same bullets, but this time they have a higher chromosomal level on their side.

The discovery furthers our understanding of a process which can often go wrong, resulting in miscarriage or infants born with Down's Syndrome, Edward's Syndrome and other chromosomal irregularities.

In leukemia and other tumours called sarcomas, exchanges of large DNA fragments occur between different chromosomes, a phenomenon known as chromosomal translocations.

These babies will have the same chromosomal makeup, and are always the same gender.