Sentences with phrase «chronic hypoxia»

Here, we show that a non-adherent, stem - like, and metastatic CSC - enriched subpopulation could be isolated by exposing human metastatic breast cancer cell lines to cycles of chronic hypoxia followed by reoxygenation.

Therefore, the primary novelty of the discoveries reported here is that programming by prenatal chronic hypoxia of cardiac and vascular dysfunction in adulthood follows the induction of oxidative stress in the fetal heart and vasculature, and that cardiac and endothelial dysfunction in adulthood can both be prevented by maternal treatment with antioxidants during pregnancy.

I also have changes to the white matter in my brain caused by chronic hypoxia ischemia.

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For example, adaptation to chronic hypoxia at high altitude can suggest targets for cardiovascular and other ischemic diseases.

Current methods for detecting hypoxia in tissue can only identify chronic hypoxia, and thus can not help doctors find aggressive cancers or acute conditions like a stroke that require immediate intervention, Chan said.

And while the adults of many estuarine invertebrates can cope with short periods of hypoxia, it has previously been unclear whether that ability is present if animals are bred and reared under chronic hypoxia.

By adulthood, these effects resolve but prenatal chronic hypoxia sets a functional deficit in both the heart and the peripheral circulation.

Canine: Determination and Mapping of Acute and Chronic Hypoxia in Canine Tumors D08CA - 077, Marlene L. Hauck, Grant Amount: $ 113,230

Cells experiencing intermittent hypoxia may be more resistant to standard therapy than cells undergoing chronic hypoxia.

According to a recent study published in the Journal of Molecular and Cellular Cardiology, an herb called Salidroside can reduce chronic hypoxia - induced Pulmonary arterial hypertension by promoting PASMCs apoptosis via an A2aR related mitochondria dependent pathway.

To study the effect of hypoxia / reoxygenation cycles on breast cancer, we exposed two metastatic human breast cancer cell lines (MDA - MB 231 and BCM2) to cycles of chronic hypoxia and nutrient deprivation.

But veterinarians who believe that brachycephalic dogs suffer more from heart issues suggest that a deficiency of oxygen over time (chronic hypoxia) causes blood channels in the lungs to narrow (pulmonary vasoconstriction) which then leads to increased blood pressure within the heart (pulmonary hypertension), a known risk for heart failure.