Sentences with phrase «coding region»
The phrase "coding region" refers to a specific part of our DNA that contains instructions to build proteins. It is like a recipe book for our bodies, where the coding region provides the "recipes" for making different proteins, which are essential for various functions in our bodies. Full definition
Copy number variation (CNV) is a common chromosomal alteration that can occur during in vitro cultivation of human cells and can be accompanied by the accumulation of mutations in coding region sequences.
completegenomics.com
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The NS5 protein coding regions of African ZIKV isolates were sequenced and aligned with representative flaviviruses sequences from GenBank to design primers and probe from conserved regions.
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In a second scheme, transcription activator - like effector nucleases (TALENs) were targeted to sequences near the translation - initiation site of CCHa2 - R to create a frame - shift mutation in the CCHa2 - R coding region [24].
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Typically we run these through our annotation pipeline, which identifies variants affecting coding regions, splice sites, and evolutionarily conserved sequences.
Like many genes, Dscam consists of protein - coding regions called exons interspersed with noncoding regions.
Study 1, led by researchers in Germany, systematically analyzed 961 tumors representing 24 molecular subtypes of pediatric cancer, including 547 whole genome sequences (~ 37x coverage genome - wide) and 414 whole - exome sequences (~ 121x coverage of coding regions only).
To identify predicted coding regions in the TMAdV genome, we used the fully annotated genome sequence of SAdV - 21 in GenBank as a reference.
Median coverage was > 2000 ×, spanning more than 99.9 % of EBOV coding regions (Fig. 1, D and E, and table S2).
Standard mapping procedures depend on homing in on informative coding regions in genes and «walking» along the chromosome, past any uninformative repetitive DNA, to the next gene.
According to Richard Durbin, who leads the project's informatics team, computer techniques seem to find most of the genes sequenced so far but frequently missed some pieces of them, particularly the short coding regions that occur at the beginning of many nematode genes.
For example, more than 33 % of the base changes they found in coding regions also alter its protein product.
Nobody knows why an invertebrate should need such a gene, but the fact that its various coding regions are organised in a subtly different way from those of all other known globin genes is forcing a rethink about the evolutionary history of globin genes.
The observed mutation rate in coding regions seems to reflect the aggressiveness of breast cancer subtypes: lower in luminal A (0.84 mutations / Mbp) than luminal B (1.36 mutations / Mbp), higher in Her2 - enriched (2.05 mutations / Mbp) and Basal - like (1.68).
SMN2 differs from the normal, functioning version of SMN1 by just a single nucleotide change: in SMN2, the sixth letter of the gene's seventh coding region, known as exon 7, is a T rather than a C.
A new paper (available here by subscription, a great summary at henry) uses 357 mtDNA coding region sequences to hypothesize about the size of the human population through time across eight major geographic regions.
Two adenovirus mRNAs have a common 5 ′ terminal leader sequence encoded at least 10 kb upstream from their main coding regions
Three mutations, located in the Aβ coding region, were detected in five patients from three families: p.Ala692Gly (Flemish), p.Glu693Lys (Italian), and p.Asp694Asn (Iowa).
Identifying functional SNPs outside of coding regions remains a challenge.
Thursday, Oct. 20, 9:30 - 9:45 am, Room 211, West Building Platform Presentation: Identifying highly constrained protein - coding regions using population - scale genetic variation J. Havrilla, University of Utah, et al
As a result, mice with an expanded HD gene produce an extra, short RNA message made of just the first coding region and part of the non-coding region.
We investigated whether the same locus is associated with TC by genotyping two SNPs around the CDH2 locus in 75 BTs, 23 SBTs and 47 GS (Table 4) and by sequencing the CDH2 coding regions in BTs.
Phylogenetic analysis of complete small subunit ribosomal RNA coding region of Myxidium lieberkuehni: evidence that Myxozoa are Metazoa and related to the Bilateria.
Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention - deficit hyperactivity disorder populations
The company will continue to be strong in its traditional high - end neighbourhoods, such as the Bridle Path, Forest Hill and Rosedale, but plans to expand into the 905 area code regions.
The 13.5 kb ws1 region contains the dsx 5 ′ UTR, promoter and presumed cis - regulatory region but notably excludes the protein coding regions of dsx or any other gene (Figure 3B).
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The researchers then analyzed another 147 colorectal cancer cell lines in the same way for kinase - domain mutations in these genes, and then sequenced the entire coding region of all kinases that were mutated, in all discovering 46 new mutations.
A failure to identify new unc - 124 alleles led us to sequence the unc - 7 coding region cloned from unc - 124 (hs10) mutants (strain HH34), and a TGC to TAC change (C238Y) in the predicted second TM domain of UNC - 7 was identified.
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Based on these results, Sebat proposes a more complex model of how autism arises, in which mothers pass on mutations affecting coding regions, which have large effects that women are protected from, while fathers pass on variants affecting noncoding regions; their effects are much more moderate and may only cause symptoms when combined with risk variants from mothers.
In many genes, coding regions called «exons» are separated by intervening «introns.»
For this purpose, we established a transgenic fly line that carries an ~ 80 - kb genomic region containing the entire CCHa2 - R coding region, as well as substantial flanking sequence.
Positional cloning ws1 shows it to fall adjacent to the protein coding region of doublesex (dsx, GeneID 100302336), a master sex determination gene found from nematodes to mammals [17], [18].
To resolve this paradox, we analyzed introns and demonstrated that these are deficient in single - nucleotide polymorphisms, as are synonymous sites in coding regions.
Regarding «Junk DNA,» yes, previous assumptions about the role of non-coding DNA have been replaced with an appreciation for other roles in regulation of coding regions, but this simply doesn't support the notion that our genomes were intelligently designed.
Research into the genetic risk for autism has mainly focused on how mutations that arise spontaneously in an individual's genome — rather than being inherited from a parent — disrupt protein - coding regions and lead to the condition.
Compared with mutations in protein - coding regions, variants in regulatory regions usually have «smaller but additive effects.
Gene discovery was greatly facilitated by a new exome sequencing technology, which analyzes all protein - coding regions of the genome at once.