Sentences with phrase «combination therapy»

Additional analyses revealed that the beneficial effects of combination therapy were stronger in heavier and more dependent smokers.

He currently serves as a principal investigator for several international clinical trials evaluating the use of novel combination therapies with the goal of targeting resistance, reducing toxicity, and improving patient outcome.

My research efforts are focused on identifying novel combination therapies for breast cancer and the mechanisms that lead to drug resistance.

As a result, there is now a push to develop combination therapies, in which different but complementary treatments are used to boost the immune response.

The aim of the grant program is to support projects that address critical unanswered research questions that will help move the field towards new device / drug combination therapies.

Researchers have now found a way to map those alternate routes by studying individual cancer cells, suggesting approaches for developing more effective combination therapies.

Patients on fixed - dose combination therapy are more likely to continue to take their pills and are more likely to take them as directed by their physician.

The researchers say their method offers a new explanation for how to prevent cancer cells from becoming treatment - resistant and how combinations therapies can be developed to overcome drug resistance.

For some cancers, treatment will consist of a single type of therapy, while others may require combination therapy (2 or more different therapies).

Despite the use of aggressive combination therapies, patients have a median survival of 15 months and less than 5 percent of them survive five years after diagnosis.

We anticipate opening the trial to younger patients in coming months, as well as incorporating combination therapies.

Many studies have shown that patient satisfaction is greater with a T4 / T3 combination therapy.

In my veterinary clinical experience, combination therapy with behavioral modifications work best for aggression and anxiety in dogs and cats.

This dietary intervention was used alongside traditional drugs as a sort of combination therapy.

Pembrolizumab, which has already been shown safe and effective as monotherapy for advanced, non-squamous non-small cell lung cancer (NSCLC), might also be an effective component in combination therapy for the disease.

Critics of the Lasker citation emphasize that development of the artemisinin - based combination therapy used today resulted from a scientific relay race that went through many stages.

Gilead has a second hepatitis C combination therapy using sofosbuvir in late - stage development.

This study tested a new combination therapy in immuno oncology and found encouraging response rates with omaveloxolone plus ipilimumab or nivolumab in patients who were checkpoint inhibitor naïve or resistant.

The Cancer Research Institute has focused its time and resources in the last decade on combination therapies because of the potential for magnified results.

In the dose - finding phase, patients received 5 mg axitinib twice daily for 7 days, followed by combination therapy with 10 mg / kg avelumab every 2 weeks and 5 mg axitinib twice daily.

In general, the response rates were higher in the ≥ 5 % PD - L1 mucosal melanoma group, although responses were still observed in the < 5 % PD - L1 group among both patients who received monotherapy and those who received combination therapy.

Optimism about combination therapy with artemisinin - related drugs is tempered by a recent study finding that the malaria parasite may be only one simple mutation away from becoming resistant to artemisinin.

Short - term estrogen - progestin combination therapy did not show an increase in risk.

«Encouraging results from combination therapy in Hodgkin lymphoma.»

Croydon, London About Blog Croydon Chiropractor, Osteopath and Physiotherapists bring combination therapy for a whole body approach to wellness.

Adams says more research is needed — such as identifying biomarkers, testing combination therapies and expanding clinical study to larger patient cohorts.

Combination therapy resulted in significantly reduced growth compared to controls (P < 0.001), and tumors treated with MIA - 602 (P < 0.05) or doxorubicin (P < 0.001)(figure 1b).

Also, the research showed that this localised delivery of combination therapy significantly inhibited the recurrence of cancer after a primary tumour was surgically removed.

The two groups will be compared to see if the neoadjuvant combination therapy improves outcomes over the standard of care.

«It's an interesting possibility — we might need different combination therapies for males and females,» says Jenkins.

Mice treated with such combination therapy survived significantly longer than mice just treated with the Angiopoietin - 2 antibody.

Patient 1 was a woman aged 65 years with metastatic melanoma admitted to a hospital with atypical chest pain, dyspnea, and fatigue 12 days after initiating combination therapy with ipilimumab and nivolumab.

Dogs with fungal discospondylitis may require lifelong treatment with antifungal drugs.3 In cases of Brucella - positive dogs, combination therapy consisting of doxycycline and an aminoglycoside is indicated.5 Corticosteroids are generally contraindicated because of possible impairment of the immune system.3

Moreover, this administration strategy can integrate with other immunomodulators (such as anti-CTLA-4) to achieve combination therapy for enhancing anti-tumor efficacy.

Review: mood stabilisers monotherapy as effective as combination therapy for treatment of acute bipolar depression in studies with some limitations

While combination therapy survival rates average around one year, approximately 20 % of dogs survive more than two years with currently available treatments.

Together, our data suggest that clinical studies may be warranted to evaluate the therapeutic potential of ABL allosteric inhibitors and to determine whether combination therapies that incorporate these compounds are effective in treating metastatic breast cancer.

This analysis found that combination therapy helped to eliminate minimal residual disease (MRD) in young AML patients who initially had a poor response to chemotherapy.

The heart team, which includes surgeons and cardiologists, takes combination therapies — including other minimally invasive procedures (TAVI, MitraClip)-- into account when deciding on the most low - impact treatment appropriate to the patient's health.

In the end, a vaccine will probably need to take multiple approaches at once, like combination therapy against cancer, says Jeffery Taubenberger of the National Institute of Allergy and Infectious Diseases.

University of California - San Francisco Combination therapy against EGFR and PI3 - kinase in glioma

Furthermore, deaths should be declining as well because combination therapy that inhibits the progress of the disease has been available since 1996 and the states» AIDS Drug Assistance Programs have been covering the cost of care for many people who can least afford it since 1987.

«The discovery raises new questions about STAT3 biology and points the way to future anti-cancer approaches, including combination therapies of coiled - coil STAT3 inhibitors in tandem with other agents,» he said.

Phase 1b study of a novel immunotherapy combination therapy of intralesional Coxsackievirus A21 and systemic ipilimumab in patients with advanced melanoma.

Combination therapies often include multiple types of chemotherapy or chemotherapy combined with other treatment options.

In either case, it will be very important both upfront and as we look at combination therapies, to determine which patients optimally benefit and if they are the patients with defects in homologous recombination who should be tested for genetic changes with the functional homologous recombination defect assay that I mentioned earlier.

A study evaluating combination therapy with aminocaproic acid, N - acetyl - cysteine with vitamins B, C, and E failed to detect a benefit.

The Sandpiper Trial is evaluating the proposed combination therapy in patients with non-small cell lung cancer (NSCLC) no longer responsive to chemotherapy.