Sentences with phrase «comparative genomics»

As computational biologists, they employ comparative genomic approaches to understand the evolution and function of protein families and their ultimate role in human disease.

Most OR and VR genes were identified by comparative genomic techniques and therefore, in many of those cases, only their protein coding sequences are defined.

Professor Matt Bellgard has developed expertise in the areas of comparative genomic analysis, computational biology, molecular evolution, bioinformatics, integrated system development and pattern recognition.

The Uppsala node is lead by Kerstin Lindblad - Toh, a professor of comparative genomics at Uppsala University who is also involved in research at the Broad Institute of Harvard and MIT, a world - leading American biomedical centre that served as a model for and inspired the infrastructural consolidation of BMC.

Firstly, both species have well characterised genomes with highly accurate and well annotated assemblies [5, 17] and have both been used frequently in comparative genomic analyses resulting in many easily accessible pairwise alignment datasets available on the UCSC genome browser [18].

44) Lockwood WW *, †, Chari R *, Chi B, Lam WL (2006) Recent advances in array comparative genomic hybridization technologies and their applications in human genetics.

He has been working on comparative genomics using domestic animals as study objects the last 30 years.

Using our own data and publically available data from array comparative genomic hybridization (aCGH), we identified a minimal deletion for the cardiomyopathy associated with del1p36 that included only the terminal 14 exons of the transcription factor PRDM16 (PR domain containing 16), a gene that had previously been shown to direct brown fat determination and differentiation.

But Alan Bittles, adjunct professor at the centre for comparative genomics at Murdoch University and fellow of the American Association for the Advancement of Science, responded: «There's a level of arrogance in comparing a smoking campaign with interfering in people's intimate relationships.»

Construction of pseudomolecule sequences of the aus rice cultivar kasalath for comparative genomics of Asian cultivated rice

This sequencing is an important part of a field known as comparative genomics.

The workshop will also serve as a platform for participants to establish multidisciplinary collaborations in comparative genomics research among various groups of scientists and researchers at national and international level.

Comparative genomics reveals insights into avian genome evolution and adaptation.

We are interested in genome - wide computational analysis and comparative genomics focusing on species biology and natural history.

Third, genes involved in pheromone detection are often species - specific and functional orthologues are typically lacking in the human genome, which confound their detection by comparative genomic methods [22].

Comparative genomics shows that rs174575 is in a sequence conserved between human (hg17), chimpanzee (panTro1), dog (canFAm1), rat (rn3), and mouse (mm5) having regulatory potential (40), and there are nonhuman animal models for dietary deprivation / supplementation (41) and for the study of intelligence (42).

The data and software resources generated by the researchers are publicly available and will empower other comparative genomic researchers to exploit plant diversity to identify genes associated with a trait of interest or agronomic value.

Further comparative genomic hybridization (CGH) analysis revealed that the majority of phenotypically diverse progeny are aneuploid.

Alu - insertion polymorphisms are a boon for the study of human population genetics and primate comparative genomics because they are neutral genetic markers of identical descent with known ancestral states.

This release of EnsemblFungi contains updated data for 12 species along with updated peptide comparative genomics, gene families and BioMarts.

Based on comparative genomic data, as well as a mathematical model of gene flow, the authors further estimate that between 1 and 4 % of the genomes of people in Eurasia may be derived from Neandertals.

The development of «bioinformatic packages» for the analysis of genetic variability and genotype - phenotype relationships will be of great value for any basic and applied comparative genomics research issues.

The committee also defined criteria that behavioral research and comparative genomics experiments — which often only involve taking blood samples — should meet in order to be approved.

Rubin says, «There are jewels in this junk that comparative genomics allows us to pick out.

Thus, this study of a major vertebrate class highlights the future promise of large - scale comparative genomics, and we hope sets the stage for an approach for sequencing and analyses of many more genomes of birds and other vertebrate lineages.

The International Oryza Map Alignment Project: development of a genus - wide comparative genomics platform to help solve the 9 billion - people question

Using a refined version of a technique called comparative genomic hybridization, but using detection devices called microarrays that were about four times as powerful as those used in prior studies, along with a suite of powerful quantitative analysis tools, the team was able to consistently resolve much smaller genomic irregularities than previously possible.

hominis species (~ 20 % divergence at the DNA level in coding sequences) will enable comparative genomic studies which are not feasible with the very closely related species C. parvum and C. hominis.

The workshop is designed to enable participants to use comparative genomic tools through lectures and hands - on practical to extract biological meanings and discover novel genes from the vast amount of genomic data and solving problems of their research interest.

2012 In this thesis, I investigate the genetics of neuropsychiatric disorders by analysing large data sets derived from high - throughput experiments, using novel comparative genomics approaches.

Robust comparative genomics relies on extensive and correct metadata.»

microbial comparative genomics.

To address these questions, we are developing and improving comparative genomics approaches such as Forward Genomics to associate phenotypic changes between species to changes in genomic elements.

The goal of this project is to identify the specific nucleotide sequences and / or single nucleotide polymorphisms that are correlated with expression of virulence and disease via comparative genomic analysis between B. pseudomallei strains as well as between various bacteriophages harbored within B. pseudomallei.

Community - led comparative genomic and phenotypic analysis of the aquaculture pathogen Pseudomonas baetica a390T sequenced by Ion semiconductor and Nanopore technologies

Polysaccharides utilization in human gut bacterium Bacteroides thetaiotaomicron: comparative genomics reconstruction of metabolic and regulatory networks.

The use of this metadata standard by all ongoing and future GSCID sequencing projects will provide a consistent representation of these data in the BRC resources and other repositories that leverage these data, allowing investigators to identify relevant genomic sequences and perform comparative genomics analyses that are both statistically meaningful and biologically relevant.

The research, employing techniques such as comparative genomics and molecular biology, could ultimately help agronomists improve crop yields for a hungry world.

Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma.

Kerstin Lindblad - Toh, professor in comparative genomics at Uppsala University and director at SciLifeLab in Uppsala, is awarded the prize» for her studies on mammalian genetics, which has led to the identification of the functional parts of the genetic code».