Sentences with phrase «cytotoxic drugs»
Cytotoxic drugs are medicines that can kill or damage cells in the body. They are used to treat diseases like cancer by targeting and destroying cancer cells. Full definition
In laboratory experiments the researchers mimicked the way SOX9 is stabilised in brain tumour cells and showed that SOX9 turned on 40 to 50 genes in the tumour to make it more resistant to standard treatment with cytotoxic drugs and more prone to spread.
sciencedaily.com
Conventional transplant conditioning employs radiation and / or high - dose cytotoxic drugs (also known as alkylators) to destroy the bone marrow and blood and immune cells; it also causes widespread cellular damage throughout the body.
It appears that, as the team expected, the test could be used to identify probable cytotoxic drugs.
They do this by making a lot more of a transport protein on the food - vacuole membrane that acts like a selective drug pump (multidrug - resistant cancer cells have evolved a similar mechanism to expel cytotoxic drugs).
Autoimmune disorders, which may manifest with granulomas on both the skin and other surfaces, are treated corticosteroids to reduce any inflammation and with chemotherapy, using cytotoxic drugs to suppress the immune system.
We recently developed a mouse strain, which can be easily reconstituted without previous conditioning (irradiation or treatment with cytotoxic drugs) and we therewith defined all parameters involved in successful HSC transplantation.
GT's lead oncology drug candidate, OXS - 1550 (DT2219) is a novel bispecific scFv recombinant fusion protein - drug conjugate composed of the variable regions of the heavy and light chains of anti-CD19 and anti-CD22 antibodies and a modified form of diphtheria toxin as its cytotoxic drug payload.
Cancer - fighting drugs (cytotoxic drugs), including cyclophosphamide, methotrexate and doxorubicin, have toxic effects on cells and are commonly used in chemotherapy to kill cancer cells.
In this award winning partnership our Centre for Drug Development is sponsoring a Phase 1 / 2a study of BT1718, a first - in - class bicyclic peptide conjugated to a cytotoxic drug being developed by Bicycle Therapeutics.
For instance, the tumor can spread more easily and it gets more resistant to standard treatment with cytotoxic drugs.
This results in the accumulation of the cytotoxic drug in cells with disabled efflux mechanisms and reduces resistance.
In these cases, treatment decision is based on an analysis of biomarkers of response and resistance to cytotoxic drugs.
Most importantly, MX - 1 tumors, which are completely resistant to doxorubicin, were very responsive to the cytotoxic drug (doxorubicin) when it was administered in combination with MIA - 602.
The role of pro-inflammatory cytokines in cancer treatment - induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs
A combination of corticosteroids, cytotoxic drugs, and antibiotics, with maintenance of nutrient and fluid intake may be helpful in some cases.
Cats with FIP are often treated with corticosteroids, cytotoxic drugs, and antibiotics.
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